Rohit Sharma's side have lost all their three games so far and RCB too have been pinned down twice quite resoundingly.
Last game at the Wankhede was a run-feast, will it be the same this time? Here is our pre-match report.
Two big sides
Head-to-head: Mumbai have dominated Bangalore
Both sides have faced each other 21 times in IPL and Mumbai Indians have a 13-8 lead against Royal Challengers Bangalore.
Interestingly, in the last two seasons, Mumbai have beaten Bangalore on all four occasions.
The momentum is with MI in terms of the dominance they have enjoyed.
In Mumbai, the sides have met 7 times with MI slightly ahead with a 4-3 margin.
MI need to crack it up at Wankhede
MI have lost two matches already at home this season. Interestingly, both were nail biting encounters. But now it is time for them to taste success and nothing better than breaking from the ifs and what could be moments. They need to come out stronger.
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Some big names to light up Wankhede
There are some serious world class players that will be taking the field on Tuesday.
It is important for the big guns to fire in this crucial encounter.
Both sides need a win badly to keep their hopes alive.
Probable Playing XI- Mumbai Indians
Suryakumar Yadav, Evin Lewis, Rohit Sharma (captain), Ishan Kishan (wicket-keeper), Kieron Pollard, Hardik Pandya, Krunal Pandya, Mayank Markande, Akila Dananjaya, Mustafizur Rahman and Jasprit Bumrah.
Probable Playing XI - Royal Challengers Bangalore
Quinton de Kock (wicket-keeper), Brendon McCullum, Virat Kohli (captain), AB de Villiers, Mandeep Singh, Sarfaraz Khan, Chris Woakes, Yuzvendra Chahal, Washington Sundar, Umesh Yadav and Kulwant Khejroliya.