Manchester City won their match on Saturday and are a point above the Reds after 31 games each.
Jurgen Klopp's side needs nothing but a win to maintain the pressure.
Here is the detailed match preview.
Liverpool vs Spurs: Team news
The Reds will need to monitor the fitness of right-back Trent Alexander Arnold, who had withdrawn from the England squad for the Euro 2020 Qualifiers.
Xherdan Shaqiri also missed games for Switzerland and needs assessment.
Joe Gomes and Alex Oxlade-Chamberlain are sure absentees.
For Spurs, Eric Dier is out after suffering a muscle injury on international duty.
Harry Winks and Serge Aurier are out.
View point from both managers
Liverpool manager Klopp said, "Their skills are important. Their attitude and character is important. But to believe in something makes it more likely to happen. The problem is Man City believe as well!"
Spurs boss Mauricio Pochettino claimed, "We are still romantic, but not many people are romantic. You must convince people to sign for your club.
Prediction and key players to watch out for
Sadio Mane is Liverpool's main goal-scoring threat at the moment.
He will be the essential point in their three-man attacking quartet.
Virgil van Dijk is key in defense and needs to rally the side.
For Spurs, talisman Harry Kane will want to breach Liverpool's defensive unit.
Liverpool have the advantage at Anfield and their added desire to fight for title could see them win.
How to pick the winning Dream11 team?
We have gone for a 4-3-3 formation starting with Alisson Becker on goal.
The four-man defense sees Toby Alderweireld and Van Dijk form the central partnership.
Injury issues see versatile Jan Vertonghen come in at right-back.
In-form Andrew Robertson is on the left.
Georginio Wijnaldum, Christian Eriksen and James Milner form the mid-field trio.
Mane (captain) and Roberto Firmino support Kane (vice-captain) in attack.
Liverpool vs Tottenham: Stat attack
Liverpool have lost just one of their past 13 league and cup matches against Tottenham.
Spurs last won at Anfield in May 2011.
Liverpool are unbeaten in 36 Premier League home games. (W 26, D 10).
Mohamed Salah has managed to score just one goal in his last 10 games.
Spurs haven't won in their last four EPL matches (L 3, D 1).
When and where to watch the match?
The match is scheduled to start at 9:00 PM IST. It will be telecast live on the Star Sports network. Fans can stream the match on Hotstar app as well (paid subscription). Meanwhile, Cardiff host Chelsea prior to this game.