CSK have won both their matches so far this season in contrast to Royals, who are yet to win.
Another victory for MS Dhoni's side will make things difficult for Royals.
Here is the detailed match preview and pitch report.
Head-to-head meetings between the two sides
The two sides have met each other 20 times in the IPL. CSK enjoy a 12-8 advantage. At the Chepauk, they have played on six occasions. CSK have a tally of 5-1 at home. They go in as the clear favorites.
CSK's depth in batting gives them the edge
CSK's batting has depth and the quality in their ranks is suited for every surface on offer.
Shane Watson played to his strengths against Delhi and got a quick-fire 44.
MS Dhoni and Kedar Jadhav took the side home with match-winning knocks.
The presence of Suresh Raina provides stability.
RR will need to play smart cricket to stop this CSK's batting unit.
CSK's top notch bowling attack will cause problems
CSK spinners have accounted for 10 scalps this season in two matches and they could rule the proceedings. Harbhajan Singh, Imran Tahir and Ravindra Jadeja are genuine match-winners. All-rounder Dwayne Bravo can pick wickets at any stage. Deepak Chahar will lead the pace attack.
RR's batting will be tested by CSK spinners
The top-order of Royals has done well so far and the variety could serve them well.
But it won't be an easy task facing an in-form spin attack.
A lot will rely on Jos Buttler, who would look to lay a strong foundation.
Their application will turn out to be vital on this track.
RR's bowling a cause of concern
RR are in need of quality death specialists. The absence of such a bowler was one of the reasons for their loss against SRH on Friday. Jofra Archer and Jaydev Unadkat will need to step up. All eyes will be on spinner Shreyas Gopal.
CSK vs RR: Pitch report, TV listing and timing
The Chepauk Stadium's pitch was disappointing when CSK and RCB played the opener.
So all eyes will be on the surface, which is expected to assist spinners at large.
The match is scheduled for a 08:00 PM IST start.
The match will be telecast live on the Star Sports Network and can be streamed on Hotstar app as well.