Both teams have played well this season and have qualified for the playoffs.
DC are currently top of the standings, whereas, CSK lie second.
There is everything to play for in order to battle for the top two spots.
Here's the detailed match preview.
Head-to-head meetings between the two teams
The two teams have met each other 19 times in the IPL. CSK have emerged victorious in 13 games, while Delhi have managed to win only six. In their previous meeting this season, CSK beat DC by six wickets.
CSK have work to do in batting
MS Dhoni is likely to feature for CSK after taking a rest in the previous encounter.
CSK's batting suffered heavily against Mumbai Indians and the southern giants will need to rectify most parts of their game.
A lot will depend on the top order in making things easier.
The lower middle order needs to come out and play well against an in-form DC bowling.
CSK have been dominating with the ball
Imran Tahir might return to the line-up. He has been CSK's main threat all season. Harbhajan Singh has done well at the Chepauk and Dhoni will be continuing with the veteran spinner. The likes of pacers Deepak Chahar and Dwayne Bravo are key personnel.
DC hope to revolve around Dhawan and Iyer
Shikhar Dhawan has peaked at the right time for DC.
After the initial struggles this season, Dhawan has been consistent for the outfit.
This bodes well for the side, who will look up to Dhawan's experience on a testing pitch.
Shreyas Iyer has played to his strengths.
DC's batting will revolve around these two players.
The likes of Rishabh Pant will want to deliver.
DC bowlers will need to rally around Rabada
Kagiso Rabada has been the main strength for DC with the ball. The Purple Cap holder has 25 wickets to his name. He will once again look to dictate the show. DC have bowled well as an unit. The others will hope to chip in.
Pitch report, timing and TV listing
Spin will be of utmost significance on this slow track at the Chepauk Stadium.
Both teams will need to plan properly and not rush things.
The hosts would want to bat well after losing the plot in the previous match.
The match is set to be telecast live on the Star Sports Network.