In one of the biggest shockers of the 2017 Australian Open, Novak Djokovic was handed a shocking defeat by world number 117 Denis Istomin.
Defending champion and world number two lost 7-6(10-8), 5-7, 2-6, 7-6(7-5), 6-4 in four hours and 48 minutes.
It is first time since 2008 Wimbledon that Djokovic lost in the second round of a Grand Slam.
2017 Australian Open - Day 4 Updates!
Leander Paes bows out in the very first round
Leander Paes and his Brazilian partner Andre Sa lost to 10th seeded pair of Treat Huey and Max Mirnyi in the first round of men's doubles to crash out of the tournament.
After having a one-set advantage the pair lost 6-4, 6-7 (3-7), 4-6.
At the opening match of the Auckland Classic earlier this year, Paes and Sa had defeated the same pair.
Another loss for Indian men in doubles
Indian pair of Divij Sharan and Purav Raja, who were the runners-up at the 2017 Aircel Chennai Open, were handed a first round defeat of 6-7 (9-11), 6-7 (4-7) by French pair Fabrice Martin and Jonathan Eysseric.
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Wozniacki, Serena advance into round three
Former world number one Caroline Wozniacki continued her impressive run at the tournament with a 6-1, 6-3 win over young Croatian Donna Vekic to reach round three.
Second seeded Serena Williams also won her second round match against Lucie Safarova of Czech Republic in straight sets of 6-3, 6-4. She will now meet Nicole Gibbs in the next round.
Radwanska sent home packing
In yet another upset of the tournament, third ranked Agnieszka Radwanska was sent home by Mirjana Lucic-Baroni in the second round women's singles match, after a 3-6, 2-6 loss in just over an hour.
Raonic, Monfils, Nadal move ahead
Third seeded Milos Raonic went past Gilles Muller in the second round to win the match 6-3, 6-4, 7-6(7-4).
Gael Monfils sealed his third-round sport as he overcame a third set lapse in a 6-3, 6-4, 1-6, 6-0 win against Alexandr Dolgopolov.
Rafael Nadal had an easy 6-3,6-1,6-3 win over Marcos Baghdatis to set up third round clash with German Alexander Zverev.