The world number one got Rory Burns and Joe Root for ducks in the first over of England's chase of 383 runs.
Cummins got Burns caught after the latter tried to flick a delivery with a close bat.
He then got Root playing the wrong line to be castled.
How did Day 4 pan out?
Jos Buttler helped England save the follow-on in the first innings. Broad and Archer were superb, but Smith held on. Root's side is in need of a miracle at Old Trafford and things look bleak for them. Losing two wickets hurt them badly.