However, the star player went down 3-6, 3-6 to hand Kerber her third Grand Slam.
Serena played well at the Flushing Meadows and reached the final.
However, a one-sided final awaited her.
Japan's Naomi Osakawon 6-2, 6-4 in a controversial and emotional summit clash.
Serena made a return in 2018 at Roland Garros
Serena missed the Australian Open 2018 and made her return to the Slams at Roland Garros. She got off to a strong start but pulled out of her fourth-round clash with Maria Sharapova. This was due to a pectoral injury since having a baby.
Serena loses two more Slam finals in 2019
In 2019, Serena bowed out in the quarters of the Australian Open.
Karolina Pliskova beat Serena 6-4, 4-6, 7-5.
The veteran was ousted by unseeded American Sofia Kenin 6-2, 7-5 in the third round of the French Open.
At the Wimbledon, a repeat telecast awaited Serena.