Their last victory against the champions came at White Hart Lane in October 2016.
Jose and Pep have faced each other on 22 occasions in their respective careers.
Pep has won 11 matches against Jose, besides losing five and drawing six.
Spurs have kept just two clean sheets under Jose
Spurs have claimed just a solitary point from a possible 18 this season against teams above them in the table prior to the Saturday's matches.
A defeat for Spurs will see them become the sixth club to lose 400 top-flight home matches.
The hosts have kept just two clean sheet in 17 league and cup games under Jose.
City have scored in 23 successive away league matches
Man City have scored in each of their last 23 away league games.
This is the third-longest such run in the competition's history.
The defending champions have won 11 of their last 12 league matches in London.
The only exception was a 2-0 defeat by Chelsea in December 2018.
City are unbeaten in their last five league matches.
Pep Guardiola plays down Jose Mourinho rivalry
Pep Guardiola opened up on his rivalry with Jose.
"Maybe we are older and more experienced. I don't know. I know every time when we were at [Manchester] United or here, it was just about my press conference if I say something or if he say something," he said.
"From my side, I always had incredible respect for what he did for football."
Timing, TV listing and match prediction
The match is set to start at 10:00 PM IST. One can watch the match live on the Star Sports Network and stream the same on Hotstar (paid subscription). Given Spurs' defensive woes, City enter the tie as favorites. They will look to outwit Spurs.