Scientists build synthetic "mini-brain" scaffold for disease research
UC Riverside researchers have invented BIPORES, a fully synthetic structure that lets real human neurons grow and organize—no animal stuff needed.
This could make studying brain diseases and testing treatments way more personal and accurate.
How does BIPORES work?
BIPORES is a tiny, maze-like scaffold made from polyethylene glycol (PEG).
It's built so neural stem cells can attach and form natural clusters, all without added proteins.
Its porous design keeps cells healthy by letting oxygen and nutrients flow easily.
Why does this matter?
Neurons grown on BIPORES actually show unique activity based on the donor, making it great for long-term studies of brain injuries or diseases.
It also means scientists can test drugs on patient-specific cells instead of animals.
The team is now working to scale up the system for even bigger breakthroughs in human disease research.