Scientists create 1st fully synthetic human brain model

Technology Nov 23, 2025

Scientists at UC Riverside have built BIPORES, the first fully synthetic 3D human brain model that grows real human neural stem cells—no animal parts or protein coatings needed.
Their work just dropped in Advanced Functional Materials.

What makes BIPORES special?

BIPORES uses a clever mix of bioprinting and microfluidics to create a sponge-like structure from polyethylene glycol.
This setup lets nutrients and oxygen flow easily, closely copying the look and feel of actual brain tissue.

Why does this matter?

Stem cells attach to BIPORES and grow into working brain cell clusters that can be studied for longer periods due to the scaffold's stability.
This means better research on how our brains work, new ways to test drugs, and less need for animal testing in the future.