Enzymes that help prostate cancer survive identified
Researchers have found two enzymes, PDIA1 and PDIA5, that help prostate cancer cells survive and resist treatment.
By blocking these enzymes in lab and animal studies, scientists saw cancer cells die off and tumors shrink—even more so when paired with a common prostate cancer drug.
PDIA1 and PDIA5 protect the androgen receptor
PDIA1 and PDIA5 protect the androgen receptor (AR), a protein that fuels tumor growth, keeping it stable so cancer can thrive.
When these enzymes are blocked, AR breaks down, energy production in the cell gets disrupted, and stress levels inside the cell spike—making it much harder for the cancer to survive.
Prostate cancer affects over 1.5 million men worldwide each year
Prostate cancer affects over 1.5 million men worldwide each year.
This discovery could lead to new treatments that target these enzymes directly.
While more research is needed to make sure healthy cells aren't harmed, it's a promising step toward better therapies for patients in the future.