Sperm donor with cancer-causing gene fathers nearly 200 children
What's the story
A sperm donor with a genetic mutation that increases cancer risk has unknowingly fathered at least 197 children across Europe, according to an investigation by 14 European public service broadcasters. The mutation, which affects the TP53 gene, is linked to Li-Fraumeni syndrome and poses a high lifetime cancer risk. The European Sperm Bank in Denmark sold the sperm, but it wasn't used by UK clinics. However, some British families undergoing fertility treatment in Denmark were affected and have been informed.
Investigation findings
Investigation reveals widespread use of cancer-risk sperm
The sperm donor, who began donating in 2005 as a student, was healthy and passed screening checks. However, the mutation occurred before his birth, damaging the TP53 gene, which prevents the body's cells from turning cancerous. While most of the donor's body does not contain the dangerous form of TP53, up to 20% of his sperm does contain it. This has led to children with the mutation having it in every cell of their bodies.
Health impact
Cancer cases and concerns among families with affected children
Out of 67 children known to have the mutation, 10 have been diagnosed with cancer. Some children have developed multiple cancers, and some have died at a young age. Families are advised to contact their clinics for more information. The European Sperm Bank has expressed sympathy to affected families and admitted that too many babies were conceived using this donor's sperm in some countries.
Regulatory debate
Calls for stricter regulations on sperm donation
The case has sparked debates over the need for stricter regulations on sperm donation. Currently, there are no international laws on how many times a donor's sperm can be used worldwide. Individual countries set their own limits; Belgium allows six families per donor, while the UK permits 10. The European Society of Human Reproduction and Embryology has recently suggested limiting donors to 50 families to reduce the social and psychological implications of having numerous half-siblings.