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San Francisco named world's most startup-friendly city
This highlights a major shift in economic opportunities from countries to cities

San Francisco named world's most startup-friendly city

Jan 29, 2026
04:33 pm

What's the story

San Francisco has been named the world's most start-up friendly city, according to a recent report by Multipolitan. The ranking highlights a major shift in economic opportunities from countries to cities. The Multipolitan Startup Friendly City Index assesses global cities based on factors like entrepreneurial activity, innovation, talent development and business agility. These elements together paint a picture of thriving start-ups and their impact on future work and urban life.

Economic influence

Start-ups' wider impact on urban ecosystems

The report emphasizes that start-ups have a far-reaching effect on urban ecosystems. They recycle local wealth, nurture future talent, and indicate an openness to new ideas. These businesses draw global talent, revitalize neighborhoods, and often transform city life in terms of co-working spaces, cultural hubs, food scenes and nightlife.

Innovation hub

San Francisco's unmatched start-up ecosystem

San Francisco's top spot in the index is due to its unparalleled venture capital ecosystem, a high concentration of start-ups and a mature innovation network. The city provides founders with access to funding, expertise and scale that few places can match. But it's not just about business fundamentals; San Francisco also offers an appealing lifestyle with its iconic cable cars, culturally rich neighborhoods, vibrant arts scene and natural beauty.

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Urban influence

Cities as engines of innovation

The index reveals that cities, not countries, are the real engines of innovation. Proximity is key in these urban ecosystems where founders can meet investors informally and talent can move quickly between companies. When cities get this right, they become magnets for entrepreneurs, students, creatives, digital nomads, and travelers seeking energy and opportunity.

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City characteristics

Traits of leading start-up cities

The index identifies several traits common among top start-up cities. These include easy access to funding and investors, strong talent pipelines from universities and global migration, supportive policies and regulatory flexibility. It also highlights the importance of digital infrastructure for rapid scaling and a culture that embraces risk, failure and reinvention. When these elements come together, cities don't just support start-ups but continuously reinvent themselves.

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