Genetically modified salmonella could be the future of cancer treatment
Scientists have created a special strain of Salmonella that zeroes in on colon tumors in mice.
Once inside, these bacteria self-destruct and release a protein called LIGHT, which wakes up the immune system and slows tumor growth.
Mice treated this way lived longer, giving researchers hope for new ways to tackle colorectal cancer.
How the bacteria work their magic
The engineered Salmonella waits until it's crowded inside the tumor, then bursts and releases LIGHT.
This kicks off a chain reaction—activating key immune cells (ILC3s) and building new immune hubs (mTLSs) right where they're needed most.
The result? Stronger anti-tumor defenses and more active immune fighters in the tumor zone.
From mice to humans: The road ahead
Tests in mice showed fewer and even fully controlled tumors, but humans are more complicated.
The team is now working to make this approach safer for people, since live bacteria can sometimes cause infections or inflammation.
If all goes well, clinical trials could be on the horizon to see if this "living medicine" can boost current colon cancer treatments.