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Home / News / Technology News / WHO calls off Hydroxychloroquine trial for COVID-19 treatment: Here's why
Technology

WHO calls off Hydroxychloroquine trial for COVID-19 treatment: Here's why

WHO calls off Hydroxychloroquine trial for COVID-19 treatment: Here's why
Written by Shubham Sharma
Jul 05, 2020, 11:10 am 2 min read
WHO calls off Hydroxychloroquine trial for COVID-19 treatment: Here's why

Anti-malaria drug Hydroxychloroquine (HCQ) and anti-HIV drug combination lopinavir/ritonavir will no longer be explored as potential treatments for COVID-19 by the World Health Organization (WHO). The WHO has discontinued the medicines' Solidarity trials after initial results showed they did not have any major benefit on hospitalized patients infected by the novel coronavirus. Here's all you need to know about it.

Drugs
First, a bit about these drugs

Hydroxychloroquine (HCQ) is widely manufactured and sold in India for the treatment of autoimmune diseases like rheumatoid arthritis as well as to prevent and treat malaria. Meanwhile, lopinavir/ritonavir (LPV/r) is a fixed-dose combination medication for the treatment and prevention of HIV/AIDS. It combines lopinavir with a low dose of ritonavir and is mostly recommended for use with other antiretrovirals.

Solidarity trials
Solidarity trials with HCQ and other therapies

As some small studies suggested HCQ and the HIV drugs could be used as COVID-19 treatments, WHO included them in the global Solidarity trials exploring different therapies to find a safe and effective way to treat or prevent COVID-19. The trials started off with five arms: standard care; remdesivir; hydroxychloroquine; lopinavir/ritonavir; and lopinavir/ritonavir combined with interferon.

Results
Interim results showed no benefit

After reviewing the interim results of the trial, WHO found that HCQ and lopinavir/ritonavir did not show any benefit on hospitalized patients and, therefore, decided to end these studies. "These interim trial results show that hydroxychloroquine and lopinavir/ritonavir produce little or no reduction in the mortality of hospitalized COVID-19 patients when compared to standard of care," the health body stated.

Safety issues
Some safety signals also noted

In addition to this, the agency also found some associated "safety signals" with the two aforementioned treatments. Previously, a study published in The Lancet raised alarm over increased mortality from HCQ but the WHO clarified there is no solid evidence of that for both of the drugs. Moreover, the WHO added that the safety signals will be detailed in a peer-reviewed journal.

Discontinuation
Trials to be discontinued with immediate effect

The WHO says investigators exploring these drugs as treatments for hospitalized COVID-19 patients have been asked to stop the trials with immediate effect. However, it also emphasized that its decision does not affect the possible evaluation of hydroxychloroquine or lopinavir/ritonavir in non-hospitalized patients or as pre- or post-exposure prophylaxis (preventive treatment) for the deadly disease. Notably, India, too, recommended HCQ as a preventive treatment.

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Shubham Sharma
Shubham Sharma
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Editor with over five years of experience in covering all things science, consumer tech, space tech, AI, infosec, and business. A commerce graduate from University of Lucknow. I have been handling Tech beat at NewsBytes since 2018.
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