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Home / News / Science News / New potential breast cancer drug identified
  • Science

    New potential breast cancer drug identified

    Astha Oriel
    Written by
    Astha Oriel
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    Last updated on Dec 19, 2020, 12:58 pm
    New potential breast cancer drug identified
  • Scientists have identified a molecule that can help treat breast cancer, giving hope to patients who have become resistant to traditional therapies.

    The first-in-class molecule shuts down estrogen-sensitive breast cancer in a new way, researchers said.

    First-in-class drugs are those that work by a unique mechanism - in this case, a molecule that targets a protein on the oestrogen receptor of tumour cells.

  • In this article
    Overcomes limitations of current therapies: UT Southwestern Professor How does the new drug work? Why treatment drugs fail to work over time? Blocking "protein-protein interactions" dream for cancer researchers
  • Details

    Overcomes limitations of current therapies: UT Southwestern Professor

    Overcomes limitations of current therapies: UT Southwestern Professor
  • Ganesh Raj, professor at the University of Texas Southwestern (UT Southwestern) Simmons Cancer Center said, "This is a fundamentally different, new class of agents for estrogen-receptor-positive breast cancer. Its unique mechanism of action overcomes the limitations of current therapies."

    He further said, "The new compound is a potential highly effective, next-line treatment for these patients."

  • Information

    How does the new drug work?

  • The drug works by blocking other molecules - proteins called co-factors - that also must attach to the estrogen receptor for cancer cells to multiply. The new molecule, dubbed ERX-11, mimics a peptide, or protein building block.

  • Background

    Why treatment drugs fail to work over time?

    Why treatment drugs fail to work over time?
  • Traditional hormonal drugs work by attaching to a molecule called the estrogen receptor in cancer cells, preventing estrogen from binding to the receptor, a necessary step for cancer cells to multiply.

    However, the estrogen receptor can mutate and change its shape over time so that the treatment drug no longer fits neatly with the receptor leading to the multiplication of cancer cells again.

  • Research

    Blocking "protein-protein interactions" dream for cancer researchers

    Blocking "protein-protein interactions" dream for cancer researchers
  • David Mangelsdorf, professor at UT Southwestern said, "There has been intense interest in developing drugs that block the ability of the estrogen receptor - the prime target in most breast cancers - from interacting with the co-regulator proteins that cause a tumor's growth."

    "Blocking such 'protein-protein interactions' has been a dream of cancer researchers for decades," he added.

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