Newsbytes
  • India
  • Business
  • World
  • Politics
  • Sports
  • Technology
  • Entertainment
  • Auto
  • Lifestyle
  • Inspirational
  • Career
  • Bengaluru
  • Delhi
  • Mumbai
  • Videos
  • Visual Stories
  • Reviews
  • Phone Reviews
  • Fitness Bands Reviews
  • Speakers Reviews
  • Find Cricket Statistics
Hindi
More
In the news
Supreme Court Of India
2002 Gujarat Riots
Enforcement Directorate (ED)
Maharashtra Government
University Grants Commission
Alt News
Newsbytes
Hindi
Newsbytes
User Placeholder

Hi,

Logout


India
Business
World
Politics
Sports
Technology
Entertainment
Auto
Lifestyle
Inspirational
Career
Bengaluru
Delhi
Mumbai
Videos
Visual Stories
Reviews
Phone Reviews
Fitness Bands Reviews
Speakers Reviews
Find Cricket Statistics

More Links
  • Videos

Download Android App

Follow us on
  • Facebook
  • Twitter
  • Linkedin
  • Youtube
 
Home / News / India News / India: Phase-2 trials of world's first one-shot pneumococcal vaccine soon
India

India: Phase-2 trials of world's first one-shot pneumococcal vaccine soon

India: Phase-2 trials of world's first one-shot pneumococcal vaccine soon
Written by Pratyush Deep Kotoky
May 04, 2022, 10:39 am 2 min read
India: Phase-2 trials of world's first one-shot pneumococcal vaccine soon
Usually, pneumococcal vaccines are administered in four shots for children and in two shots for adults.

India is set to begin the phase-2 trials of the world's first one-shot pneumococcal vaccine for adults soon. Manufactured by Hyderabad-based Biological E, the phase-2 trials of the vaccine are likely to begin in July, involving 250 participants. Phase-1 trials were concluded earlier this year. To note, pneumococcal vaccines are usually administered in two shots for adults and four shots for children.

Context
Why does this story matter?
  • Pneumococcal vaccines protect against bacteria that cause pneumococcal diseases such as bacteremia, bacterial pneumonia, and meningitis.
  • Any infection caused by bacteria called Streptococcus pneumoniae, or pneumococcus, is called pneumococcal disease.
  • Pneumococcal diseases are broadly classified into invasive and non-invasive (mucosal) forms.
  • Notably, as per a study, India has the highest mortality and morbidity due to invasive pneumococcal disease among adults aged above 50 years.
Details
Duration of phase-1 trials was 35 days

The phase-1 trials of the investigational vaccine candidate were conducted earlier this year to assess the safety, reactogenicity, tolerability, and immunogenicity of a single intramuscular dose in healthy adults aged 18-45 years. There were reportedly 60 participants in the trials, which were held only at one trial site in the country. The duration of the phase-1 trials was 35 days for each participant.

Vaccine
Vaccine will provide over 85% serotype protection

As per the trial protocol synopsis submitted to drug regulator CDSCO, Biological E's candidate "pneumococcal polysaccharide conjugate vaccine (24Valent)" could provide serotype protection of over 85% in India. This is because it includes the most prevalent serotypes in India. The most prevalent serotypes in India reportedly include 14, 5, 1, 19F, 6B, 6A, 19A, 23F, 22F, 3, 9V, 18C, 4, 7F, 33F, and 17.1.

Composition
'Important to evaluate circulating serotype in a particular country'

The protocol synopsis also highlighted the importance of evaluating circulating serotypes in a particular country to select a "suitable vaccine to ensure maximum efficacy and cost‐effectiveness." Citing a recent study in India, it said, "54% of the pneumococcal isolates belonged to PCV‐10 and 73% to PCV‐13." Biological E's vaccine contains polysaccharides from PCV13's 13 serotypes and 11 additional serotypes specific to India, it added.

Share this timeline
Facebook
Whatsapp
Twitter
Linkedin
Pratyush Deep Kotoky
Pratyush Deep Kotoky
Twitter
Pratyush Deep Kotoky covers national and politics news at NewsBytes. His over three-year-long career involves reporting on sociopolitical issues across India, particularly the northeast region. His previous stints include 101Reporters, The Sunday Guardian, and Inshorts, and he has also written for Asia Times, Firstpost, and Newslaundry. He has a postgraduate degree in Journalism from the Indian Institute of Mass Communication, Delhi.
Latest
India
Vaccine
Central Drugs Standard Control Organization (CDSCO)
Biological E
Related
Latest
5 books of Leo Tolstoy you have to read!
5 books of Leo Tolstoy you have to read! Lifestyle
2022 Wimbledon: Ons Jabeur thrashes Diane Parry in third round
2022 Wimbledon: Ons Jabeur thrashes Diane Parry in third round Sports
Charu Asopa, Rajeev Sen's divorce turns messy with mutual allegations
Charu Asopa, Rajeev Sen's divorce turns messy with mutual allegations Entertainment
Harmanpreet Kaur surpasses 3,000 ODI runs: Key stats
Harmanpreet Kaur surpasses 3,000 ODI runs: Key stats Sports
5 air travel hacks when flying with kids
5 air travel hacks when flying with kids Lifestyle
India
Formula E confirms Hyderabad E-Prix for February 2023
Formula E confirms Hyderabad E-Prix for February 2023 Auto
Hero Lectro e-cycles become cheaper thanks to Rs. 15,000 subsidy
Hero Lectro e-cycles become cheaper thanks to Rs. 15,000 subsidy Auto
Bengaluru Airport installs diaper changing room in men's washroom
Bengaluru Airport installs diaper changing room in men's washroom Lifestyle
Who is Mohammed Zubair, journalist arrested for hurting religious sentiments?
Who is Mohammed Zubair, journalist arrested for hurting religious sentiments? India
Sri Lanka under virtual lockdown over fuel scarcity amid crisis
Sri Lanka under virtual lockdown over fuel scarcity amid crisis World
More News
Vaccine
COVID-19: India logs 11,793 new cases, 27 more deaths
COVID-19: India logs 11,793 new cases, 27 more deaths India
COVID-19: India reports 17,073 new cases; 21 more deaths
COVID-19: India reports 17,073 new cases; 21 more deaths India
COVID-19 vaccines prevented 42L deaths in India in 2021: Report
COVID-19 vaccines prevented 42L deaths in India in 2021: Report India
COVID-19: India logs 12,249 fresh cases, 13 more fatalities
COVID-19: India logs 12,249 fresh cases, 13 more fatalities India
COVID-19: India logs 9,923 fresh cases, 17 more fatalities
COVID-19: India logs 9,923 fresh cases, 17 more fatalities India
More News
Central Drugs Standard Control Organization (CDSCO)
Expert panel recommends emergency use authorization for Zydus's three-dose vaccine
Expert panel recommends emergency use authorization for Zydus's three-dose vaccine India
J&J withdraws vaccine approval request in India, CDSCO says
J&J withdraws vaccine approval request in India, CDSCO says India
Government expert panel recommends conducting trials on mixing Covishield, COVAXIN
Government expert panel recommends conducting trials on mixing Covishield, COVAXIN India
Expert panel says no to Covovax's children trials in India
Expert panel says no to Covovax's children trials in India India
COVAXIN phase 2/3 trials for 2-18-year-olds recommended by expert panel
COVAXIN phase 2/3 trials for 2-18-year-olds recommended by expert panel India
More News
Biological E
35 lakh doses of J&J COVID-19 vaccine reach Kasauli lab
35 lakh doses of J&J COVID-19 vaccine reach Kasauli lab India
Biological E-manufactured J&J's single-dose COVID-19 vaccine in India by October
Biological E-manufactured J&J's single-dose COVID-19 vaccine in India by October India
Phase 2/3 trials of Corbevax on 5-18 age group permitted
Phase 2/3 trials of Corbevax on 5-18 age group permitted India
How Biological E's coronavirus vaccine could be a potential gamechanger
How Biological E's coronavirus vaccine could be a potential gamechanger India
India's neighbors train experts for clinical trials of COVID-19 vaccine
India's neighbors train experts for clinical trials of COVID-19 vaccine India
More News
Related
COVID-19 oral vaccine's clinical trial to begin in India soon
COVID-19 oral vaccine's clinical trial to begin in India soon India
Next News Article
Next News Article

Love India news?

Subscribe to stay updated.

India Thumbnail
India News Business News World News Politics News Sports News Technology News Entertainment News Auto News Lifestyle News Inspirational News
Career News Bengaluru News Delhi News Mumbai News Mukesh Ambani Indian Premier League (IPL) Karnataka Samsung Xiaomi West Bengal
Bihar Virat Kohli Rohit Sharma Haryana Narendra Modi Arvind Kejriwal Tamil Nadu Gujarat Yogi Adityanath YouTube
Instagram Hollywood News Uttar Pradesh Kerala Netflix Bollywood News Mamata Banerjee Maruti Suzuki Rahul Gandhi Elon Musk
Shah Rukh Khan Chelsea FC OPPO Akhilesh Yadav Indian Cricket Team Apple Manchester United Salman Khan Cryptocurrency OnePlus
Amitabh Bachchan ICC Women's World Cup Vivo India vs Sri Lanka
About Us Privacy Policy Terms & Conditions Contact Us Ethical Conduct Grievance Redressal News News Archive Topics Archive IPL 2022 Schedule IPL 2022 Points Table Find Cricket Statistics
Follow us on
Facebook Twitter Linkedin Youtube
All rights reserved © NewsBytes 2022